HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium hydride → 1-(triisopropylsilyl)-1H-indol-6-ol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium hydride | HCID 24758 | — |
| Edukt | Triisopropylsilyl chloride | HCID 139400 | — |
| Edukt | 6-(benzyloxy)-1H-indole | HCID 260804 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 1-(triisopropylsilyl)-1H-indol-6-ol | HCID 67226331 | — |
Reaktionsschritte
6-Benzyloxy-indole (1.0 g) was treated with NaH (135 mg) and triisopropylsilyl chloride (1.0 g) in tetrahydrofuran for 1 hour, purified by flash chromatography (98/2 ethyl acetate/hexanes), then debenzylated in ethanol (35 mL) using Pearlman's catalyst (0.19 g) and a hydrogen balloon.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08586754B2 |
| Quelldatensatz | uspto-grants-2013_11 |
| ORD ID | ord-c69a23ead7154ae3ae4bbdfbb94c8fc1 |
| Quellennotiz | uspto-grants-2013_11 |