Potassium vinyltrifluoroborate → 1-t-Butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

HRID 2045698Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2045698
[CH:1]([B-](F)(F)F)=[CH2:2].[K+].Br[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[O:19][CH3:20])[N:15]=[C:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH:13]=[C:12]2[O:27][C@H:28]1[CH2:32][N:31]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[C@H:30]([C:40]([O:42][CH3:43])=[O:41])[CH2:29]1>CCO.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[CH3:20][O:19][C:18]1[CH:17]=[C:16]2[C:11]([C:12]([O:27][C@H:28]3[CH2:32][N:31]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[C@H:30]([C:40]([O:42][CH3:43])=[O:41])[CH2:29]3)=[CH:13][C:14]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[N:15]2)=[CH:10][C:9]=1[CH:1]=[CH2:2]

Komponenten

5

Edukt 2

HCID 23679353Potassium vinyltrifluoroborateHCID 58005143HCID 58005143, Verbindung

Produkt 1

HCID 595711221-t-Butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-phenyl-6-vinylquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylateAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418807HCID 178418807, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Potassium vinyltrifluoroborate (5.05 g, 37.7 mmol), TEA (5.25 mL, 37.7 mmol) and PdCl2(dppf)-CH2Cl2 adduct (1025 mg, 1.26 mmol) were added to a solution of the product from step 5 (14.0 g, 21.5 mmol) in EtOH (300 mL). The mixture was then heated to reflux for 1.5 h, at which time LC-MS revealed the disappearance of starting material. The reaction mixture was cooled and concentrated and partitioned between EtOAc and water. The layers were separated, and the organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified on silica gel (gradient elution 10% to 80% EtOAc in hexanes) to give the title compound (10.4 g, 82% yield). LRMS (M+H)+ Calcd.: 505.2; found 505.5.

Aufarbeitung

  1. temperatureThe mixture was then heated
  2. temperatureto reflux for 1.5 h, at which time LC-MS
  3. temperatureThe reaction mixture was cooled
  4. concentrationconcentrated
  5. custompartitioned between EtOAc and water
  6. customThe layers were separated
  7. dry with materialthe organic layer was dried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated
  10. customThe residue was purified on silica gel (gradient elution 10% to 80% EtOAc in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-c714fa6c75544bdaa98282d390afbfd4
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08591878B2

Notizen zur Reaktion

Wird geladen…