Sodium Hydroxide → 2-(4,6-Dimethyl-5-nitropyrimidine-2-ylamino)acetic acid

Temperatur

25 °C

Compound 10 (80 mg) was suspended in 1,4-dioxane (1.5 mL) and a 2N aqueous sodium hydroxide solution (1.5 mL) was added at room temperature (20 to 30° C.). The mixture was stirred at room temperature (20 to 30° C.) for 8 hours. Subsequently, the mixture was washed with diethyl ether. While the reaction mixture was cooled, a 2N aqueous HCl solution was added portionwise to neutralize the mixture to a pH of 3. The mixture was extracted twice with chloroform and the organic layer was concentrated under reduced pressure to give 52 mg (75% yield) of the desired product as a pale yellow amorphous.

1. washSubsequently, the mixture was washed with diethyl ether
2. temperatureWhile the reaction mixture was cooled
3. additiona 2N aqueous HCl solution was added portionwise
4. extractionThe mixture was extracted twice with chloroform
5. concentrationthe organic layer was concentrated under reduced pressure

ORD-Eintrag

ord-73840c9e39d24b83b73ea951f2ea1fe9

Quelldatensatz

uspto-grants-2013_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08592435B2