2-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one → 2-Amino-7-(3-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one

HRID 2046478Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2046478
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)[CH2:6][C:5]1=O)(=O)[CH3:2].[NH2:19][C:20]1[N:29]=C(C)C2C(=O)CC(C3C=CC(F)=CC=3)CC=2[N:21]=1>>[NH2:29][C:20]1[N:21]=[C:1]([CH3:2])[C:4]2[C:9](=[O:10])[CH2:8][CH:7]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=3)[CH2:6][C:5]=2[N:19]=1

Komponenten

3

Edukt 2

HCID 172212082-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-oneHCID 582693722-Acetyl-5-(3-fluoro-phenyl)-cyclohexane-1,3-dione

Produkt 1

HCID 582694052-Amino-7-(3-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one

Versuchsvorschrift

The title compound was prepared from 2-acetyl-5-(3-fluoro-phenyl)-cyclohexane-1,3-dione (100 mg, 0.42 mmol), from stage 1, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/a stage 2/3) except that the title compound was further purified by recrystallisation in methanol.

Aufarbeitung

  1. customwas further purified by recrystallisation in methanol

Quellen und Nachweise

ORD-Eintrag
ord-9f61dc8d778a4679a84e807badacabb4
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592430B2

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