HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 2-Chloromaleic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | Gantacurium | HCID 10102486 | — |
| Edukt | Chlorofumarate | HCID 21982578 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 2-Chloromaleic acid | HCID 5284488 | — |
Reaktionsschritte
Gantacurium, an asymmetrical chlorofumarate, was prepared in four chemical transformations from compound (XIIIB) using minor modifications of previously reported chemistry, see WO2005/041960. Isoquinolylalkanol compound (XIIIB) was condensed with trans-2,3-dichlorosuccinic anhydride and triethylamine in acetonitrile solvent to provide a monoester of chlorofumaric acid, which was then condensed with isoquinolylalkanol compound (XIIIC):
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08592451B2 |
| Quelldatensatz | uspto-grants-2013_11 |
| ORD ID | ord-bfa23cbf96724e8aae7a97aca570a95b |
| Quellennotiz | uspto-grants-2013_11 |