Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate → HCID 178515484, Verbindung

HRID 2047054Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2047054
O=[C:2]([CH:9]1[CH2:18][CH2:17][C:12]2([O:16][CH2:15][CH2:14][O:13]2)[CH2:11][CH2:10]1)[CH2:3][C:4]([O:6]CC)=O.[NH2:19][C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>CCO>[O:13]1[C:12]2([CH2:11][CH2:10][CH:9]([C:2]3[CH:3]=[C:4]([OH:6])[N:21]4[N:22]=[CH:23][CH:24]=[C:20]4[N:19]=3)[CH2:18][CH2:17]2)[O:16][CH2:15][CH2:14]1

Komponenten

4

Edukt 2

HCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoateHCID 178418806HCID 178418806, Verbindung

Produkt 1

HCID 178515484HCID 178515484, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a 20 mL scintillation vial containing ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate (11.7 mmol, 3.00 g) is added 3-amino-1H-pyrazole (11.7 mmol, 973 mg). The two oils were mixed and heated neat at 100° C. for 3 hours. The resulting off-white solid was dissolved up in EtOH (100 mL) and reduced in vacuo to remove water formed during cyclization. This solid was used in the next step without further purification.

Aufarbeitung

  1. additionThe two oils were mixed
  2. customto remove water
  3. customformed during cyclization
  4. customThis solid was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-9f8dc6d1a07f461ab43307203fe1e194
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08591943B2

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