Hydrochloric Acid → HCID 66733508, Verbindung

HRID 2047186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2047186
[NH2:1][C:2]1[N:7]2[N:8]=[CH:9][C:10]([C:11]3[CH:12]=[N:13][C:14]4[C:19]([CH:20]=3)=[CH:18][CH:17]=[CH:16][CH:15]=4)=[C:6]2[N:5]=[C:4]([N:21]2[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]2)[C:3]=1Br.[ClH:35]>O1CCOCC1>[Cl:35][C:3]1[C:4]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[N:5][C:6]2[N:7]([N:8]=[CH:9][C:10]=2[C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:2]=1[NH2:1]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66738195Tert-butyl 4-(7-amino-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate

Produkt 1

HCID 66733508HCID 66733508, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

tert-Butyl 4-(7-amino-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carboxylate (0.09 mmol) was charged to a 20 mL scintillation vial. To this vial was added 4N HCl in 1,4-dioxane. The reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo and 6-chloro-5-(piperazin-1-yl)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine was used without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo and 6-chloro-5-(piperazin-1-yl)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine
  2. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4040204f335646e9b452a053ed4da597
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08591943B2

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