Methyl 3-oxovalerate → HCID 66745629, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[C:3]([C:19]#[N:20])=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][CH2:6][C:7]([CH3:15])([CH3:14])[C:8]([NH:10][CH2:11][CH2:12][CH3:13])=[O:9].O=[C:22]([CH2:28][CH3:29])[CH2:23][C:24]([O:26][CH3:27])=[O:25]>>[CH3:27][O:26][C:24]([C:23]1[C:22]([CH2:28][CH3:29])=[N:1][C:2]2[C:3]([C:19]=1[NH2:20])=[C:4]([O:5][CH2:6][C:7]([CH3:15])([CH3:14])[C:8](=[O:9])[NH:10][CH2:11][CH2:12][CH3:13])[CH:16]=[CH:17][CH:18]=2)=[O:25]Komponenten
3
Versuchsvorschrift
Prepared as in Example 2a from 3-(3-amino-2-cyanophenoxy)-2,2-dimethyl-N-propylpropan-amide (Tachdjian, C. et al. PCT Int. Appl. 2008, WO 2008154221) and methyl 3-oxopentanoate as a yellow solid (17%). 1H NMR (400 MHz, DMSO-d6) δ 0.75 (t, J=8.0 Hz, 3H), 1.17 (t, J=8.0 Hz, 3H), 1.26 (s, 6H), 1.40 (m, 2H), 2.84 (q, J=8.0 Hz, 2H), 3.04 (q, J=8.0 Hz, 2H), 3.85 (s, 3H), 4.13 (s, 2H), 6.88 (d, J=8.0 Hz, 1H), 7.27 (dd, J=8.0 Hz, 1H), 7.51 (t, J=8.0 Hz, 1H), 7.81 (m, 3H). MS 388 (MH+).
Quellen und Nachweise
- ORD-Eintrag
- ord-bd57b3ef8bb94d4fa8ae3b0c9c116717
- Quelldatensatz
- uspto-grants-2013_11