Diethyl (ethoxymethylene)malonate → Ethyl 4-hydroxy-6-propoxyquinoline-3-carboxylate

Beteiligte Stoffe

Reaktionsschritte

Prepared as in Example 1c from 4-propoxyaniline and diethyl 2-(ethoxymethylene)malonate as a white solid (65%). 1H NMR (400 MHz, DMSO-d6) δ 0.98 (t, J=7.2 Hz, 3H), 1.25 (t, J=7.2 Hz, 3H), 1.72-1.77 (m; 2H), 3.98 (t, J=6.0 Hz, 2H), 4.16-4.21 (m, 2H), 6.97-6.99 (m, 1H), 7.53-7.56 (m, 2H), 8.47 (d, J=5.2 Hz, 1H), 12.27 (s, 1H). MS 276 (MH+).

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