Ethanol → 5-Methyl-2,3-dihydro-1-benzofuran-7-amine

HRID 2047974Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2047974
[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.C(O)C>ClCCl.[C].[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:11])[C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1

Komponenten

5

Edukt 2

HCID 702EthanolHCID 552848275-Methylbenzofuran-7-amine

Produkt 1

HCID 552848285-Methyl-2,3-dihydro-1-benzofuran-7-amineAusbeute 87,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

Aufarbeitung

  1. customfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
  2. customThe catalyst was removed by celite filtration
  3. customcondensed under reduced pressure
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-86d4d71fdc3a44b6863b61629630334a
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592593B2

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