Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate → 4'-{[4-(2-Methoxy-1-methylethyl)-2-methyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrile

HRID 2048233Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2048233
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([C:22](=O)[CH2:23][CH2:24][CH3:25])[C:17](OCC)=[O:18])=[CH:11][CH:10]=1)#[N:2].[CH3:27][O:28][CH2:29][CH:30]([NH:32][C:33]1[NH:37][C:36]([CH3:38])=[N:35][N:34]=1)[CH3:31]>>[CH3:27][O:28][CH2:29][CH:30]([N:32]1[C:17](=[O:18])[C:16]([CH2:15][C:12]2[CH:13]=[CH:14][C:9]([C:4]3[C:3]([C:1]#[N:2])=[CH:8][CH:7]=[CH:6][CH:5]=3)=[CH:10][CH:11]=2)=[C:22]([CH2:23][CH2:24][CH3:25])[N:34]2[N:35]=[C:36]([CH3:38])[N:37]=[C:33]12)[CH3:31]

Komponenten

3

Edukt 2

HCID 10020734Ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxohexanoateHCID 178495283HCID 178495283, Verbindung

Produkt 1

HCID 670091964'-{[4-(2-Methoxy-1-methylethyl)-2-methyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]methyl}biphenyl-2-carbonitrileAusbeute 58,8 %

Reaktionsbedingungen

Temperatur
250 °C

Versuchsvorschrift

A mixture of ethyl 2-[(2′-cyanobiphenyl-4-yl)methyl]-3-oxohexanoate (1.84 g) and N-(2-methoxy-1-methylethyl)-5-methyl-4H-1,2,4-triazol-3-amine (0.4 g) was stirred at 250° C. for 15 min under microwave irradiation. The obtained reaction mixture was purified by silica gel column chromatography to give the title compound as a colorless solid (0.63 g, 52%).

Aufarbeitung

  1. customThe obtained reaction mixture
  2. customwas purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-1944ed8e4dfb460a876bdbe28c5a4724
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08592431B2

Notizen zur Reaktion

Wird geladen…