(+/-)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid → (+/-)-4,5-dihydro-4-fluoro-(3-mercapto-2-methyl-1-oxopropyl)-1H-pyrrole-2-carboxylic acid
Reaktionsgleichung
C([S:4][CH2:5][CH:6]([CH3:18])[C:7]([N:9]1[CH2:13][CH:12]([F:14])[CH:11]=[C:10]1[C:15]([OH:17])=[O:16])=[O:8])(=O)C.C(SCC(C)C(N1CCC=C1C(O)=O)=O)(=O)C>>[F:14][CH:12]1[CH2:13][N:9]([C:7](=[O:8])[CH:6]([CH3:18])[CH2:5][SH:4])[C:10]([C:15]([OH:17])=[O:16])=[CH:11]1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
By substituting (±)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-4,5-dihydro-4-fluoro-1H-pyrrole-2-carboxylic acid for the (±)-1-[3-(acetylthio)-2-methyl-1-oxopropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid in the procedure of Example 2, (±)-4,5-dihydro-4-fluoro-(3-mercapto-2-methyl-1-oxopropyl)-1H-pyrrole-2-carboxylic acid is obtained.