5-Hydroxypipecolic acid → Methyl L-prolinate

HRID 2049798

Reaktionsgleichung

Reaktionsgleichung von HRID 2049798
[CH3:1][O:2][C:3](=[O:12])[CH:4]1[CH2:9][CH2:8][CH:7]([O:10][CH3:11])C[NH:5]1.OC1CNC(C(O)=O)CC1>>[CH3:11][O:10][CH:7]1[NH:5][C@H:4]([C:3]([OH:2])=[O:12])[CH2:9][CH2:8]1.[CH3:1][O:2][C:3](=[O:12])[C@@H:4]1[CH2:9][CH2:8][CH2:7][NH:5]1

Komponenten

4

Edukt 2

HCID 1517305-Hydroxypipecolic acidHCID 570630145-Methoxypipecolic acid methyl ester

Produkt 2

HCID 853477Methyl L-prolinateHCID 705881305-Methoxyproline

Versuchsvorschrift

By substituting 5-methoxypipecolic acid methyl ester [preparing from 5-hydroxypipecolic acid by the procedure described in J. Chem. Soc. 429 (1945) for 5-methoxyproline] for the L-proline methyl ester in the procedure of Example 18, 2,3-dehydro-1-(3-acetylthio-1-oxopropyl)-5-methoxypipecolic acid is obtained.

Quellen und Nachweise

ORD-Eintrag
ord-bc345ec6ab4d4c7291360d648715cb9e
Quelldatensatz
uspto-grants-1980_04
Patentnummer
US04198515

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