Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | Phosphinic Acid | HCID 4124402 | — |
| Edukt | 2-Hydroxy-2-(4-hydroxyphenyl)acetic acid, sodium salt hydrate | HCID 23698133 | — |
| Edukt | HCID 178527018 | HCID 178527018 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | Hydroxyphenylacetic acid | HCID 127 | 67% |
Reaktionsschritte
A stirred mixture of sodium p-hydroxymandelate monohydrate (21.2 g.), potassium hypophosphite (52 g.), 50% w/v aqueous hypophosphorous acid (2.2. ml.) and water (10 ml.) is heated under reflux for 22 hours (internal temperature 143° C.) and then cooled. The mixture is diluted with water, acidified with hydrochloric acid and extracted with methyl isobutyl ketone. p-Hydroxyphenylacetic acid, which is formed in 67% yield, is isolated from the extract by conventional means.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US04198526 |
|---|
| Quelldatensatz | uspto-grants-1980_04 |
|---|
| ORD ID | ord-e5a7f46740e04d07bec40324c7d375f1 |
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| Quellennotiz | uspto-grants-1980_04 |
|---|
