Methanol → Methanone, [4-(methoxymethyl)phenyl]phenyl-

HRID 2049905Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2049905
[OH-:1].[K+].Cl[CH2:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1.[CH3:19]O>>[CH3:19][O:1][CH2:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 30163764-(Chloromethyl)benzophenone

Produkt 1

HCID 111774Methanone, [4-(methoxymethyl)phenyl]phenyl-Ausbeute 88,5 %

Versuchsvorschrift

To 4 liters of absolute methyl alcohol was added 300 grams (4.5 moles) of 85% potassium hydroxide pellets with mechanical stirring. The amount of 618 grams (2.7 moles) of 4-(chloromethyl)benzophenone was added to the resulting warm solution. The reaction mixture was refluxed for three hours, filtered with suction, and concentrated. Water was added and the lower oily layer was separated and distilled to provide 530 grams (88.5% yield) of 4-(methoxymethyl)benzophenone as an almost colorless liquid (b.p. 140° C., 0.20 mm Hg). The infrared spectrum revealed a carbonyl band at 1660 cm-1. Ultraviolet analysis revealed λ max (ε) at 256 nanometers (18,380).

Aufarbeitung

  1. temperaturewarm solution
  2. temperatureThe reaction mixture was refluxed for three hours
  3. filtrationfiltered with suction
  4. concentrationconcentrated
  5. additionWater was added
  6. customthe lower oily layer was separated
  7. distillationdistilled

Quellen und Nachweise

ORD-Eintrag
ord-d6f35dde5676480ebece24b69144e9d8
Quelldatensatz
uspto-grants-1980_04
Patentnummer
US04199420

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