N-(3-benzoylthiopropanoyl)-L-alanine → N-(3-Sulfanylpropanoyl)-L-leucine

Reaktionsgleichung

C([S:9][CH2:10][CH2:11][C:12]([NH:14][C@H:15]([C:20]([OH:22])=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:13])(=O)C1C=CC=CC=1.C(SCCC(N[C@H](C(O)=O)C)=O)(=O)C1C=CC=CC=1>>[SH:9][CH2:10][CH2:11][C:12]([NH:14][C@H:15]([C:20]([OH:22])=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:13]

Komponenten

Edukt 2

HCID 13036931N-(3-benzoylthiopropanoyl)-L-alanine

HCID 13036933N-[3-(Benzoylsulfanyl)propanoyl]-L-leucine

Produkt 1

HCID 13036942N-(3-Sulfanylpropanoyl)-L-leucine

Versuchsvorschrift

By substituting N-(3-benzoylthiopropanoyl)-L-leucine (6.46 g.) for the N-(3-benzoylthiopropanoyl)-L-alanine in the procedure of Example 2, 2.75 g. of N-(3-mercaptopropanoyl)-L-leucine are obtained, m.p. 131°-132°. This material is recrystallized from acetonitrile.

Quellen und Nachweise

ORD-Eintrag: ord-448cec575dc64dc486b99e25a556a9a1
Quelldatensatz: uspto-grants-1980_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04199512

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