HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3',4'-Dehydrovinblastine → methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3',4'-Dehydrovinblastine | HCID 151120 | — |
| Edukt | Alumina | HCID 9989226 | — |
| Produkt | methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate | HCID 442111 | — |
Reaktionsschritte
Following the procedure described in the Example 19 but performing the oxidation in the presence of aluminium oxide used in a five-fold amount related to the anhydrovinblastine the title compound is prepared. The quality of the aluminium oxide employed corresponds to the activity grade I or II. The reaction is completed within two hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04199505 |
| Quelldatensatz | uspto-grants-1980_04 |
| ORD ID | ord-b4512ff0f39047f8a868dcdd7e930e22 |
| Quellennotiz | uspto-grants-1980_04 |