Potassium Carbonate → [1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide

HRID 2050

Reaktionsgleichung

Reaktionsgleichung von HRID 2050
[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].Cl[CH2:21][P:22](=[O:25])([CH3:24])[CH3:23].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([N:5]1[C:14](=[O:15])[C:13]2[N:12]([CH2:21][P:22](=[O:25])([CH3:24])[CH3:23])[CH:11]=[N:10][C:9]=2[N:8]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6]1=[O:7])[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 1014211,3-Dibutylxanthine

Produkt 1

HCID 19689263[1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

5 g (0.01 9 mol) of 1,3-dibutylxanthine were stirred at 80° C. for 6 hours with 2.88 g (0.0228 mol) of chloromethyldimethylphosphine oxide and 3.2 g (0.0228 mol) of potassium carbonate in 80 ml of DMF. The solution was cooled to room temperature and filtered, and the filtrate was concentrated under reduced pressure. The residue which remained was crystallized in petroleum ether/ethyl acetate.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue which remained was crystallized in petroleum ether/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-20ece88fc4e64225b2c8a9f117afb490
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728686

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