HCID 19380545, Verbindung → HCID 178513639, Verbindung

HRID 2050431Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2050431
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH:7]=[C:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[O:19])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1>[Pt].C.O1CCOCC1.C(N(CC)CC)C>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[CH2:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:15]=[CH:16][C:17]([C:18]([NH2:20])=[O:19])=[CH:21][CH:22]=2)[CH2:10][CH2:9]1

Komponenten

4

Edukt 1

HCID 19380545HCID 19380545, Verbindung

Produkt 1

HCID 178513639HCID 178513639, VerbindungAusbeute 45,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 16218561HCID 16218561, VerbindungKatalysatorHCID 68453242Dioxan triethylamineLösungsmittel

Versuchsvorschrift

A mixture of 500 mg of 4-[4-[2-(1,3-dioxolan-2-yl)ethylidene]cyclohexyl]benzamide and 20 ml of dioxan/triethylamine (vol. 9:1) was hydrogenated in the presence of 500 mg of 10 percent platinum-charcoal for 2 hours. The reaction mixture was then filtered and the filtrate was evaporated. Recrystallization of the evaporation residue from 40 ml of dioxan gave 230 mg of 4-[trans-4-[2-(1,3-dioxolan-2-yl)ethyl]cyclohexyl]benzamide as colorless crystals.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered
  2. customthe filtrate was evaporated
  3. customRecrystallization of the evaporation residue from 40 ml of dioxan

Quellen und Nachweise

ORD-Eintrag
ord-f990f42e8bff4699a1bc38b023b90f57
Quelldatensatz
uspto-grants-1991_05
Patentnummer
US05013477

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