Phosgene → 3-(3-Phenylpropyl)phenyl isocyanate

HRID 2051025

Reaktionsgleichung

Reaktionsgleichung von HRID 2051025
[C:1](Cl)(Cl)=[O:2].[C:5]1([CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=2)[NH2:17])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1(C)C=CC=CC=1>[C:5]1([CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[C:16]([N:17]=[C:1]=[O:2])[CH:18]=[CH:19][CH:20]=2)[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 6371Phosgene2×HCID 4273073-(3-Phenylpropyl)aniline

Produkt 1

HCID 127905743-(3-Phenylpropyl)phenyl isocyanateAusbeute 95,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

170 g of phosgene are dissolved in 200 ml of toluene at -10° C. At the same temperature, 145 g of 3-(3-phenylpropyl)-aniline in 300 ml of toluene are then slowly added dropwise. The mixture is warmed slowly, the introduction of phosgene is started when 60° C. is reached, and the mixture is brought to the boil. After 6 hours, excess phosgene is flushed out with nitrogen and the mixture is distilled. 156 g of 3-(3-phenylpropyl)-phenyl isocyanate, of boiling point 107°-110° C./0.1 mbar, are obtained.

Aufarbeitung

  1. temperatureThe mixture is warmed slowly
  2. customwhen 60° C.
  3. customexcess phosgene is flushed out with nitrogen
  4. distillationthe mixture is distilled

Quellen und Nachweise

ORD-Eintrag
ord-e98f2dc5aac7494cb6f021de28743477
Quelldatensatz
uspto-grants-1991_05
Patentnummer
US05015762

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