Sodium Hydroxide → 4,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane

HRID 2051369

Reaktionsgleichung

Reaktionsgleichung von HRID 2051369
[OH-].[Na+].[CH3:3][C:4]1([CH3:13])[CH:9]([CH3:10])[CH2:8][CH2:7][CH:6]([CH3:11])[C:5]1=[O:12].[Cl-].[CH3:15][S+](C)C>CS(C)=O>[CH3:13][C:4]1([CH3:3])[CH:9]([CH3:10])[CH2:8][CH2:7][CH:6]([CH3:11])[C:5]21[O:12][CH2:15]2

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 51304442,2,3,6-TetramethylcyclohexanoneHCID 10176118Trimethylsulfonium chloride

Produkt 1

HCID 187910594,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

According to a preferred embodiment of the invention, NaOH is added to a mixture consisting of 2,2,3,6-tetramethyl-1-cyclohexanone and trimethylsulfonium chloride in dimethylsulfoxide. The reaction is slightly exothermic, hence the necessity to maintain an external cooling of the reaction mixture so as to keep the temperature at about 25°-30° C. Good stirring is also applied for about 6 hr. 4,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane is then obtained by extraction of the resulting mixture with petrol ether, concentration of the organic extracts and fractional distillation.

Aufarbeitung

  1. additionis added to a mixture
  2. temperaturehence the necessity to maintain
  3. temperaturean external cooling of the reaction mixture so as
  4. customat about 25°-30° C

Quellen und Nachweise

ORD-Eintrag
ord-f85b611f44f54e56bd406f3464041f72
Quelldatensatz
uspto-grants-1991_05
Patentnummer
US05017711

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