Sodium Hydroxide → Diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate

HRID 2051754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2051754
[OH-].[Na+].[C:3]([C:8]1[CH:28]=[CH:27][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])=[CH:10][CH:9]=1)([O:5]CC)=[O:4]>C(O)C>[C:3]([C:8]1[CH:9]=[CH:10][C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][P:19](=[O:26])([O:23][CH2:24][CH3:25])[O:20][CH2:21][CH3:22])=[CH:27][CH:28]=1)([OH:5])=[O:4]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 5271409Benzoic acid, 4-((6-(diethoxyphosphinyl)hexyl)oxy)-, ethyl ester

Produkt 1

HCID 5271411Diethyl [6-(4-carboxyphenoxy)hexyl]phosphonateAusbeute 90,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution (21 ml) of 1N sodium hydroxide in ethanol was added to a solution of 8.3 g of diethyl [6-(4-carbethoxyphenoxy)hexyl]phosphonate (Example 8) in 20 ml of ethanol. The reaction mixture was stirred at room temperature for two days. The solid fraction was collected, digested with 100 ml of ether, filtered and dried to give 7.0 g of diethyl [6-(4-carboxyphenoxy)hexyl]phosphonate in the form of its sodium salt, m.p. 215°-216° C.

Aufarbeitung

  1. customThe solid fraction was collected
  2. filtrationfiltered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e1086161db3d4d7494d7ca12ff7fbd34
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04182759

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