3-(4-Fluorophenoxy)propionic acid → 1-Propanol, 2-(4-fluorophenoxy)-

HRID 2051928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2051928
B#B.[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[C:10](O)=[O:11])=[CH:6][CH:5]=1>O1CCCC1>[F:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH:9]([CH3:13])[CH2:10][OH:11])=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 38721403-(4-Fluorophenoxy)propionic acidHCID 6328200Diboron

Produkt 1

HCID 104647301-Propanol, 2-(4-fluorophenoxy)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To 95 ml. of diborane in 95 ml. of tetrahydrofuran was added 10.2 g. of 2-(4-fluorophenoxy)propionic acid in 100 ml. of tetrahydrofuran. The reaction mixture was stirred at room temperature for 20 hours. The solution was gradually poured onto 600 g. of ice and extracted (3×-250 ml each) with chloroform. The combined organic layer was extracted with water (3×-50 ml each) and dried. The solvent was removed under vacuum giving a clear liquid.

Aufarbeitung

  1. additionThe solution was gradually poured onto 600 g
  2. extractionof ice and extracted (3×-250 ml each) with chloroform
  3. extractionThe combined organic layer was extracted with water (3×-50 ml each)
  4. customdried
  5. customThe solvent was removed under vacuum
  6. customgiving a clear liquid

Quellen und Nachweise

ORD-Eintrag
ord-2b65110274a9450c852a727ab72536fe
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04182776

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