2-Naphthalenecarboxamide, 4-amino-N-[4-[2,4-bis(1,1-dimethylpropyl)phenoxy]butyl]-1-hydroxy- → 4-(3-Amino-4-hydroxybenzenesulfonamido)-1-hydroxy-N-[4-(2,4-di-tert-pentylphenoxy)butyl]-2-naphthamide

HRID 2052196Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2052196
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[C:4]([C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([CH2:30][CH3:31])([CH3:29])[CH3:28])=[CH:23][C:22]=2[C:32]([CH2:35][CH3:36])([CH3:34])[CH3:33])=[O:14])[CH:3]=1.[OH:37][C:38]1[CH:43]=[CH:42][C:41]([S:44](Cl)(=[O:46])=[O:45])=[CH:40][C:39]=1[N+:48]([O-])=O>>[NH2:48][C:39]1[CH:40]=[C:41]([S:44]([NH:1][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([OH:12])=[C:4]([C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([CH2:30][CH3:31])([CH3:28])[CH3:29])=[CH:23][C:22]=3[C:32]([CH2:35][CH3:36])([CH3:34])[CH3:33])=[O:14])[CH:3]=2)(=[O:46])=[O:45])[CH:42]=[CH:43][C:38]=1[OH:37]

Komponenten

3

Edukt 2

HCID 30848622-Naphthalenecarboxamide, 4-amino-N-[4-[2,4-bis(1,1-dimethylpropyl)phenoxy]butyl]-1-hydroxy-HCID 36704794-Hydroxy-3-nitrobenzene-1-sulfonyl chloride

Produkt 1

HCID 233361094-(3-Amino-4-hydroxybenzenesulfonamido)-1-hydroxy-N-[4-(2,4-di-tert-pentylphenoxy)butyl]-2-naphthamide

Versuchsvorschrift

This compound was prepared in two steps by conventional procedures of the type well known in the art. 4-Amino-1-hydroxy-N-[4-(2,4-di-tert-pentylphenoxy)butyl]-2-naphthamide (U.S. Pat. No. 3,954,476, column 25) was converted to the sulfonamide by reaction with 4-hydroxy-3-nitrobenzenesulfonyl chloride. Secondly, the nitro group was reduced to the amino compound by catalytic hydrogenation.

Aufarbeitung

  1. customThis compound was prepared in two steps by conventional procedures of the type

Quellen und Nachweise

ORD-Eintrag
ord-9f7c9648c71249d988851dc0114501fb
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04183754

Notizen zur Reaktion

Wird geladen…