Methyl iodide → HCID 20377886, Verbindung

HRID 2052419Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2052419
Cl.[F:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:19][I:20]>CC(C)=O>[CH3:19][I:20].[F:2][C:3]1[CH:18]=[CH:17][C:6]([C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[O:8])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 20377895(Pyridin-3-yl)methyl 4-fluorobenzoate--hydrogen chloride (1/1)

Produkt 1

HCID 20377886HCID 20377886, VerbindungAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

4.4 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine hydrochloride prepared according to Example 1 (a) are dissolved in 40 ml. of acetone and 3 g. of methyl iodide are added thereto. The reaction mixture is refluxed for 30 minutes and then cooled to 0° C. The precipitated quaternary salt is separated by filtration and recrystallized from 100 ml. of anhydrous ethanol. 4.2 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine methyliodide (60% of theoretical yield) are obtained; m.p.: 132°-133° C.

Aufarbeitung

  1. dissolutionare dissolved in 40 ml
  2. temperatureThe reaction mixture is refluxed for 30 minutes
  3. customThe precipitated quaternary salt is separated by filtration
  4. customrecrystallized from 100 ml

Quellen und Nachweise

ORD-Eintrag
ord-03a26ac6a7954575958f0883efb484e1
Quelldatensatz
uspto-grants-1980_01
Patentnummer
US04184040

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