2-Chloro-4-t-butylbenzyl alcohol → 4-tert-Butyl-2-chlorobenzaldehyde
Reaktionsgleichung
[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
The alcohol compound (195 mg, 0.981 mmol) obtained in Step 1-3 was dissolved in chloroform (5 ml). Activated manganese dioxide (1.27 g) was added to the obtained solution, and they were violently stirred at 50° C. for 2 hours. After leaving to cool, manganese dioxide was filtered out, and the filtrate was concentrated under reduced pressure. After the purification by the silica gel column chromatography, 2-chloro-4-t-butylbenzaldehyde (yield: 152 mg, 79%) was obtained.
Aufarbeitung
- customAfter leaving
- temperatureto cool
- filtrationmanganese dioxide was filtered out
- concentrationthe filtrate was concentrated under reduced pressure
- customAfter the purification by the silica gel column chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-27fb604fb5af4837a01fa0452c05b2b7
- Quelldatensatz
- uspto-grants-2008_02
- Patentnummer
- US07326701B2
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