Methanol → HCID 178499130, Verbindung

Reaktionsgleichung

S(Cl)(Cl)=[O:2].C([O:12][C:13]1[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=2)[N:16]=[C:15]([C:29]#N)[N:14]=1)C1C=CC=CC=1.[CH3:31][OH:32]>>[CH3:31][O:32][C:29]([C:15]1[N:14]=[C:13]([OH:12])[CH:18]=[C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=2)[N:16]=1)=[O:2]

Komponenten

Edukt 3

HCID 887Methanol

HCID 24386Thionyl Chloride

HCID 588780594-Benzyloxy-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

Produkt 1

HCID 178499130HCID 178499130, Verbindung

Versuchsvorschrift

To methanol (10 ml) at 0° C. was added thionyl chloride (500 ul). The mixture was stirred for 30 minutes then 4-benzyloxy-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile (300 mg) was added and the reaction was heated to reflux for five hours. Solvent was evaporated under reduced pressure to yield crude product. Purification of the resulting residue by flash chromatography on silica afforded product 4-hydroxy-6-(3-trifluoromethylphenyl)-pyrimidine-2-carboxylic acid methyl ester (104 mg).