Phosphorus oxide (P4O10) → 2-(3-Bromo-phenyl)-1-(5-phenyl-furan-2-yl)-ethanone

Temperatur

80 °C

2-Phenyl-furan (119)(50 mg, 0.28 mmol) and (3-bromo-phenyl)-acetic acid (134 mg, 0.63 mmol) were dissolved in ortho-dichlorobenzene (4 ml). P2O5 (202 mg, 1.42 mmol) was added as a suspension in ortho-dichlorobenzene (2 ml). The reaction mixture was heated to 80° C. for 2 h and cooled to room temperature overnight. After the addition of further P2O5 (202 mg, 1.42 mmol), heating was resumed at 90° C. for 3 h. The reaction mixture was cooled to 0° C. and quenched with H2O (15 ml). The organic layer was separated and the aqueous layer was washed with DCM (3×10 ml). The combined organic layers were dried (MgSO4), filtered and the DCM removed in vacuo. The ortho-dichlorobenzene solution was loaded to a silica-gel column and flushed with heptane (100 ml). The title compound was then eluted with 10% EtOAc in heptane.

1. temperaturecooled to room temperature overnight
2. temperatureheating
3. temperatureThe reaction mixture was cooled to 0° C.
4. customquenched with H2O (15 ml)
5. customThe organic layer was separated
6. washthe aqueous layer was washed with DCM (3×10 ml)
7. dry with materialThe combined organic layers were dried (MgSO4)
8. filtrationfiltered
9. customthe DCM removed in vacuo
10. customflushed with heptane (100 ml)
11. washThe title compound was then eluted with 10% EtOAc in heptane

ORD-Eintrag

ord-d90d1e2c213944cc8e3794232f98a127

Quelldatensatz

uspto-grants-2008_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07326732B2