(2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide → (2S,3S)-N-butyl-3-amino-2-hydroxyheptanamide

HRID 2053477Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2053477
[CH2:1]([NH:5][C:6](=[O:17])[C@@H:7]([OH:16])[C@@H:8]([N:13]=[N+]=[N-])[CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH3:4]>[C].[Pd].CO>[CH2:1]([NH:5][C:6](=[O:17])[C@@H:7]([OH:16])[C@@H:8]([NH2:13])[CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 1

HCID 59655565(2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide

Produkt 1

HCID 59655570(2S,3S)-N-butyl-3-amino-2-hydroxyheptanamideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 30 ml of a methanol solution containing 304 mg (1.25 mmol) of (2S,3S)-N-butyl-3-azido-2-hydroxyheptanamide was added 30 mg of 5% palladium carbon, and the resulting mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble materials were filtered off, and the filtrate was distilled under reduced pressure to obtain 254 mg (Yield: 94%) of the title compound.

Aufarbeitung

  1. filtrationInsoluble materials were filtered off
  2. distillationthe filtrate was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-54eeba36932747d3ab2e8e016b11c279
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07326799B2

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