(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide → (2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-amino-2-hydroxyheptanamide

HRID 2053481Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2053481
[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([NH:12][C:13](=[O:24])[C@@H:14]([OH:23])[C@@H:15]([N:20]=[N+]=[N-])[CH2:16][CH2:17][CH2:18][CH3:19])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>[C].[Pd].CO>[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([NH:12][C:13](=[O:24])[C@@H:14]([OH:23])[C@@H:15]([NH2:20])[CH2:16][CH2:17][CH2:18][CH3:19])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

4

Edukt 1

HCID 59655559(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide

Produkt 1

HCID 59655562(2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-amino-2-hydroxyheptanamideAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 30 ml of a methanol solution containing 442 mg (1.27 mmol) of (2S,3S)-N-[(2S)-1-methoxy-1-oxo-3-phenyl-2-propyl]-3-azido-2-hydroxyheptanamide was added 45 mg of 5% palladium carbon, and the mixture was stirred under hydrogen atmosphere for 18 hours. Insoluble materials were filtered off, and the filtrate was distilled under reduced pressure to obtain 385 mg (Yield: 94%) of the title compound.

Aufarbeitung

  1. filtrationInsoluble materials were filtered off
  2. distillationthe filtrate was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b0e22ad2803d4bada2ac045a8c3483cf
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07326799B2

Notizen zur Reaktion

Wird geladen…