Hydrochloric Acid → HCID 68569999, Verbindung

HRID 2053523

Reaktionsgleichung

Reaktionsgleichung von HRID 2053523
[ClH:1].C(OC([N:9]1[C@H:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:11]=[C:10]1[N:26]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:27])=O)(C)(C)C>CCOC(C)=O>[ClH:1].[C:14]1([C@H:13]2[C@@H:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:11][C:10]([N:26]([CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH3:27])=[N:9]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 685697692-(N-Methylbenzylamino)-cis-4,5-diphenyl-4,5-dihydro-imidazole-1-carboxylic Acid Tert-Butyl Ester

Produkt 1

HCID 68569999HCID 68569999, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Hydrogen chloride is bubbled into a solution of 81 (110 mg, 0.25 mmol) in EtOAc (10 mL) for 1 min, and the solution is stirred at RT for 6 h. The solvent is removed by rotary evaporation, and the residue triturated with Et2O. The insoluble material is dissolved in dichloromethane and Et2O is added, and the precipitate is filtered to give 43 mg of the product 82. 1H NMR (DMSO-d6) δ 9.28 (s, 2H), 7.60-7.30 (m, 5H), 7.25-6.95 (m, 10H), 5.58 (s, 2H), 4.78 (s, 2H), 3.15 (s, 3H); MS: m/z 342 (M++1).

Aufarbeitung

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue triturated with Et2O
  3. dissolutionThe insoluble material is dissolved in dichloromethane
  4. additionEt2O is added
  5. filtrationthe precipitate is filtered

Quellen und Nachweise

ORD-Eintrag
ord-6d41629badbf44e9a104e75b090b92c9
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07326792B2

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