Hydrochloric Acid → (4S,5R)-N-[(3-fluorophenyl)methyl]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-amine;hydrochloride

Beteiligte Stoffe

Reaktionsschritte

Hydrogen chloride is bubbled into a solution of 87 (1.5 g, 3.37 mmol) in EtOAc (30 mL) for 1 min, and the solution is stirred at RT overnight. The solvent is removed by rotary evaporation, and the residue crystallized from dichloromethane and Et2O to give 1.05 g of the product 88. 1H NMR (DMSO-d6) δ 9.28 (t, 1H), 8.68 (s, 1H), 8.15 (s, 1H), 7.35-7.10 (m, 3H), 7.10-6.80 (m, 7H), 6.80-6.50 (m, 4H), 5.03 (s, 1H), 4.80-4.45 (m, 2H); MS: m/z 346 (M++1).

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