HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chlorine → 4-(2-aminomethylpiperidin-1-ylcarbonyl)-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chlorine | HCID 24526 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Piperidine-2-methylamine | HCID 90865 | — |
| Edukt | HCID 178464831 | HCID 178464831 | — |
| Lösungsmittel | Dimethyl Sulfoxide | HCID 679 | — |
| Produkt | 4-(2-aminomethylpiperidin-1-ylcarbonyl)-3-chloro-N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide | HCID 178464803 | — |
Reaktionsschritte
Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, rac.-2-aminomethylpiperidine, PFTU, and diisopropylethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 3.93 minutes; C23H25Cl2N5O2 (474.39); mass spectrum: (M−H)−=473/475/477 (chlorine isotope).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07326791B2 |
| Quelldatensatz | uspto-grants-2008_02 |
| ORD ID | ord-81a814d9d9eb4667a1c3e87896e645a1 |
| Quellennotiz | uspto-grants-2008_02 |