HCID 86598665, Verbindung → HCID 86598666, Verbindung

HRID 2054265Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2054265
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18].[NH2:21][C:22]1[C:26]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[CH:25][NH:24][N:23]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:23]3[N:24]=[CH:25][C:26]([C:27]4[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=4)=[C:22]3[N:21]=2)=[CH:4][C:3]=1[C:17]([F:20])([F:19])[F:18]

Komponenten

3

Edukt 2

HCID 86598665HCID 86598665, VerbindungHCID 178509259HCID 178509259, Verbindung

Produkt 1

HCID 86598666HCID 86598666, VerbindungAusbeute 58 %

Versuchsvorschrift

Reaction of 1-(4-methyl-3-trifluoromethyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (149 mg, 0.5 mmol), prepared from 4-methyl-3-trifluoromethyl-acetophenone according to general procedure A, and 3-amino-4-(4-pyridinyl)-pyrazole [CAS No. 216661-87-9; prepared from 4-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (80 mg, 0.5 mmol) according to general procedure B yielded the title compound as a yellow solid (122 mg, 58%). MS (ISP) 423.1 [(M+H)+]; mp 218° C.

Quellen und Nachweise

ORD-Eintrag
ord-68c9ea3b4e344f218f70ef5ed5fb9210
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07329662B2

Notizen zur Reaktion

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