Ethyl Acetate → 2-Nitro-5-(3-diethylamino-1-propoxy)aniline

HRID 2054536

Reaktionsgleichung

Reaktionsgleichung von HRID 2054536
F[C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].C(=O)([O-])[O-].[NH4+:24].[NH4+].CCOC(C)=O>CN(C=O)C>[N+:17]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:7][C:2]=1[NH2:24])([O-:19])=[O:18]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 517111Ammonium CarbonateHCID 220147332-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

Produkt 1

HCID 220147182-Nitro-5-(3-diethylamino-1-propoxy)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.

Aufarbeitung

  1. washThe combined organic layers are then washed with water and brine
  2. dry with materialdried over Na2SO4
  3. customRemoval of the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-533bc1d78966435e9472b359c24e93b1
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07329684B2

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