3,5-Dimethylaniline → 3-(3,5-Dimethylphenyl)amino-4-nitrophenol

HRID 2054629

Reaktionsgleichung

Reaktionsgleichung von HRID 2054629
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][C:13]1[CH:14]=[C:15]([CH:17]=[C:18]([CH3:20])[CH:19]=1)[NH2:16]>C(OCC)(=O)C>[CH3:12][C:13]1[CH:14]=[C:15]([NH:16][C:2]2[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])[CH:17]=[C:18]([CH3:20])[CH:19]=1

Komponenten

4

Edukt 2

HCID 79493,5-DimethylanilineHCID 5209483-Fluoro-4-nitrophenol

Produkt 1

HCID 219381543-(3,5-Dimethylphenyl)amino-4-nitrophenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

5.4 g of 3-fluoro-4-nitrophenol and 4.3 ml of 3,5-dimethylaniline were mixed and stirred for 6 hours at 120° C. After cooling, it was taken up in ethyl acetate and water and extracted three times with 1N aqueous hydrochloric acid. The combined aqueous phases were extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was crystallized.

Aufarbeitung

  1. temperatureAfter cooling
  2. extractionwater and extracted three times with 1N aqueous hydrochloric acid
  3. extractionThe combined aqueous phases were extracted three times with ethyl acetate
  4. customThe combined organic phases were dried on sodium sulfate
  5. concentrationconcentrated by evaporation in a vacuum
  6. customthe residue was crystallized

Quellen und Nachweise

ORD-Eintrag
ord-aefc4f6bdadd41ef8f4eb405ebd21e51
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07329679B2

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