Methylamine → HCID 21948911, Verbindung

Reaktionsgleichung

CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4].[CH3:16][NH2:17]>>[CH3:16][NH:17][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4]

Komponenten

Edukt 2

HCID 6329Methylamine

HCID 45089604Methyl 5-aminoquinoline-2-carboxylate

Produkt 1

HCID 21948911HCID 21948911, Verbindung

Versuchsvorschrift

76 mg (0.376 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved with 10 ml of a 2.0 M methanolic methylamine solution. After 90 minutes under reflux and another 16 hours at room temperature, the solvent is removed under reduced pressure, and the residue is purified on silica gel with hexane-ethyl acetate (0-80%). 72 mg (95% of theory) of the product is obtained.

Aufarbeitung

customthe solvent is removed under reduced pressure
customthe residue is purified on silica gel with hexane-ethyl acetate (0-80%)
custom72 mg (95% of theory) of the product is obtained

Quellen und Nachweise

ORD-Eintrag: ord-190b2443319d4cdd99f5ad69883aa279
Quelldatensatz: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07329753B2

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