Hydrochloric Acid → 3-(Pyridin-4-yl)propanoic acid

Beteiligte Stoffe

Reaktionsschritte

To a solution of ethyl 3-pyridin-4-ylpropanoate (Method 2; 103.1 g, 576 mnaol) in water (400 ml) and ethanol (20 ml) at room temperature was added potassium hydroxide (60 g, 1600 mmol). After 18 hours hydrochloric acid (100 ml) was added to give a white solid. Yield 62.8 g (73%). NMR 8.38 (d, 2H), 7.21 (d, 2H), 2.70 (t, 2H), 2.52 (t, 2H); m/z 152.2.

Herkunft & Nachweise