HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,3-Difluorobenzoyl chloride → 1'-{[6-Chloro-1-(2,3-difluorobenzoyl)-1H-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,3-Difluorobenzoyl chloride | HCID 519549 | — |
| Edukt | 1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657623 | — |
| Produkt | 1'-{[6-Chloro-1-(2,3-difluorobenzoyl)-1H-indol-3-yl]carbonyl}-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 59657579 | — |
Reaktionsschritte
Following the general procedure VII as described above, the acylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (prepared according to example 19) with commercially available 2,3-difluorobenzoyl chloride gave the title compound. ES-MS m/e (%): 539.3(M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07332501B2 |
| Quelldatensatz | uspto-grants-2008_02 |
| ORD ID | ord-04c164461dcd430892296c452f13dd64 |
| Quellennotiz | uspto-grants-2008_02 |