HCID 11287642, Verbindung → 3-(Carboxymethoxy)isoxazole-5-carboxylic acid

HRID 2056266Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2056266
C[O:2][C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:6]=1)=[O:4]>CO.[OH-].[Na+]>[C:3]([C:5]1[O:9][N:8]=[C:7]([O:10][CH2:11][C:12]([OH:14])=[O:13])[CH:6]=1)([OH:4])=[O:2]

Komponenten

4

Edukt 1

HCID 11287642HCID 11287642, Verbindung

Produkt 1

HCID 111481453-(Carboxymethoxy)isoxazole-5-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of ethyl (5-(methoxycarbonyl)isoxazol-3-yl)oxyacetate (4 mmol, Example 73) in methanol (60 mL) and 5% aqueous NaOH is heated at reflux for 1 hour. At the end of this time, the methanol is removed, the residue diluted with additional water, and acidified to pH=4 with hydrochloric acid. The resulting precipitate is collected by filtration, washed with cold water, and dried.

Aufarbeitung

  1. temperatureat reflux for 1 hour
  2. customAt the end of this time, the methanol is removed
  3. additionthe residue diluted with additional water
  4. filtrationThe resulting precipitate is collected by filtration
  5. washwashed with cold water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-12f1b06ac18f4c0ab03fe67d2a7285d8
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07335655B2

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