Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-tert-Butylbenzylamine → N-(4-tert-butylbenzyl)-2-(5-isoquinolinyl)propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-tert-Butylbenzylamine | HCID 2735655 | — |
| 반응물 | 2-(Isoquinolin-5-YL)acetic acid | HCID 12018708 | — |
| 반응물 | 2-(Isoquinolin-5-yl)propanoic acid | HCID 22337638 | — |
| 생성물 | N-(4-tert-butylbenzyl)-2-(5-isoquinolinyl)propanamide | HCID 10247056 | — |
반응 단계
The title compound was prepared using the procedure described in Example 222B using 4-(tert-butyl)benzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 347 (M+H)+; MS (ESI−) m/z 345 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.56 (d, J 7.1, 3H), 4.22 (d, J 6.1, 2H), 4.57 (q, J 7.1, 1H), 7.10 (d, J 8.5, 2H), 7.29 (d, J 8.5, 2H), 7.98 (t, J 7.5, 1H), 8.13 (d, J 7.1, 1H), 8.34 (d, J 7.8, 1H), 8.56 (d, J 6.8, 1H), 8.69 (m, 2H), 9.78 (s, 1H); Anal. Calcd for C23H26N2O+1.1 HCl:C, 71.46; H, 7.07; N, 7.25. Found: C, 71.13; H, 7.17; N, 7.02.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07335678B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-8e281ed8d2604648b3b3f56089725efd |
| 출처 메모 | uspto-grants-2008_02 |