Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride

HRID 2057845Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2057845
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[ClH:29]>CO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:1][C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1.[ClH:29]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 7019804Z-Tyr(tbu)-ome

Produkt 1

HCID 6452451Methyl O-tert-butyl-L-tyrosinate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 16218511Pd barium sulfateKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

300 g (778 mmoles) of Z-Tyr(But)-OMe (Ann. Chem. 696, 226 (1966)) are dissolved in 1 liter of methanol and hydrogenated catalytically (Pd/BaSO4 catalyst) at pH 4.5, using an auto-burette (about 2 N methanolic HCl being added). After completion of hydrogenation, the catalyst is filtered off and the filtrate is concentrated. The residue is triturated with ether.

Aufarbeitung

  1. filtrationAfter completion of hydrogenation, the catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customThe residue is triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-1056f3f79e874fd4a3a7c1eba6adf64f
Quelldatensatz
uspto-grants-1980_07
Patentnummer
US04212796

Notizen zur Reaktion

Wird geladen…