Triethylamine → HCID 12928961, Verbindung

HRID 2057941Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2057941
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[O:19]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH2:31])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1C=CC=CC=1>[O:19]([CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 788644-ChloroquinazolineHCID 235127975-Phenoxypentylamine

Produkt 1

HCID 12928961HCID 12928961, VerbindungAusbeute 19,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a solution of 1.7 g (0.01 mol) of 4-chloroquinazoline in 50 ml of benzene were added 1.0 g (0.01 mol) of triethylamine and 1.8 g (0.01 mol) of 5-phenoxypentylamine, and the mixture was refluxed for 3 hours. After completion of the reaction, the benzene was evaporated under reduced pressure to leave crystals, which were washed with water, collected by filtration and recrystallized from aqueous ethanol, giving 0.6 g of 4-(5-phenoxypentyl)aminoquinazoline in the form of colorless flakes.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 3 hours
  2. customAfter completion of the reaction
  3. customthe benzene was evaporated under reduced pressure
  4. customto leave crystals, which
  5. washwere washed with water
  6. filtrationcollected by filtration
  7. customrecrystallized from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-dd5dd1ecb4a2437183757127228f4e0d
Quelldatensatz
uspto-grants-1980_07
Patentnummer
US04213987

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