Hydrochloric Acid → Methyl O-tert-butyl-L-tyrosinate hydrochloride

HRID 2058398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2058398
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.[ClH:29]>CO.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:1][C@H:2]([C:15]([O:17][CH3:18])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1.[ClH:29]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 7019804Z-Tyr(tbu)-ome

Produkt 1

HCID 6452451Methyl O-tert-butyl-L-tyrosinate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 16218511Pd barium sulfateKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

300 g (778 mmols) of Z-Tyr(But)-OMe (Ann. Chem. 696, page 226 (1966)) were dissolved in 1 l of methanol and catalytically hydrogenated (Pd/BaSO4 catalyst) at pH 4.5 on the autoburette (addition of about 2 N methanolic HCl). When the hydrogenation was complete, the catalyst was filtered off with suction and the filtrate was concentrated. The residue was triturated with ether.

Aufarbeitung

  1. filtrationthe catalyst was filtered off with suction
  2. concentrationthe filtrate was concentrated
  3. customThe residue was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-fc7ece1ab4804c53a69a69978249eb9c
Quelldatensatz
uspto-grants-1980_07
Patentnummer
US04215037

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