4-Fluorobenzenesulfonyl chloride → Azetidine, 1-[(4-fluorophenyl)sulfonyl]-

HRID 20584

Reaktionsgleichung

Reaktionsgleichung von HRID 20584
[NH:1]1[CH2:4][CH2:3][CH2:2]1.[F:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1>C1COCC1>[F:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:1]2[CH2:4][CH2:3][CH2:2]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1

Komponenten

4

Edukt 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 10422Azetidine

Produkt 1

HCID 59346928Azetidine, 1-[(4-fluorophenyl)sulfonyl]-Ausbeute 8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Azetidine (0.25 g, 4.35 mmol) was added to a solution of sodium hexamethyldisilylazide (0.85 g, 4.6 mmol) in THF (10 mL) at 0° C. and reaction mixture stirred for 10 minutes. 4-fluorobenzenesulfonyl chloride (0.85 g, 4.35 mmol) was subsequently added and the reaction mixture was allowed to warm up to ambient temperature overnight. The reaction mixture was concentrated in vacuo and the residue taken up in ethyl acetate and water. The organic layer was separated and then dried (MgSO4), filtered and evaporated to give a waxy, yellow solid (75 mg).

Aufarbeitung

  1. customreaction mixture
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. customThe organic layer was separated
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-c32ba789be974ba99759bf5cf8743db1
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745475B2

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