Hydrate;hydrochloride → 3-Aza-spiro[5.5]undecan-9-one hydrochloride

HRID 2059920Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059920
[O:1]=[C:2]1[CH2:19][CH2:18][C:5]2([CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:4][CH:3]1C(OC)=O.[ClH:24].O>>[ClH:24].[CH2:10]1[C:5]2([CH2:18][CH2:19][C:2](=[O:1])[CH2:3][CH2:4]2)[CH2:6][CH2:7][NH:8][CH2:9]1

Komponenten

3

Edukt 2

HCID 21885828Hydrate;hydrochlorideHCID 67315804HCID 67315804, Verbindung

Produkt 1

HCID 673158423-Aza-spiro[5.5]undecan-9-one hydrochloride

Versuchsvorschrift

To 3-tert-butyl 8-methyl 9-oxo-3-azaspiro[5.5]undecane-3,8-dicarboxylate (450 mg, 1.38 mmol) was added HCl—H2O (5 ml, 1:1) at 0° C. and the mixture was refluxed overnight. LCMS revealed complete consumption of the starting material and the mixture was concentrated to dryness. The crude product thus obtained was used directly in next step.

Aufarbeitung

  1. temperaturethe mixture was refluxed overnight
  2. customconsumption of the starting material
  3. concentrationthe mixture was concentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-67fe3e5ed43e4967bd792dcb48cac8bd
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278319B2

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