Nitric Acid → 2,3-Difluoro-4-methyl-6-nitrophenol

HRID 2060002

Reaktionsgleichung

Reaktionsgleichung von HRID 2060002
[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[CH:4][C:3]=1[OH:10].[N+:11]([O-])([OH:13])=[O:12]>ClCCl>[F:1][C:2]1[C:7]([F:8])=[C:6]([CH3:9])[CH:5]=[C:4]([N+:11]([O-:13])=[O:12])[C:3]=1[OH:10]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 27741512,3-Difluoro-4-methylphenol

Produkt 1

HCID 594441602,3-Difluoro-4-methyl-6-nitrophenolAusbeute 91,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 2,3-difluoro-4-methylphenol (1 g, 6.94 mmol) in dichloromethane at 0° C. was added nitric acid 70% (0.7 mL, 7.77 mmol). After 1 h at room temperature the solution was washed with water, dried and evaporated to give 2,3-difluoro-4-methyl-6-nitrophenol (1.2 g, 6.35 mmol, 91% yield) (D44) as yellow solid.

Aufarbeitung

  1. washAfter 1 h at room temperature the solution was washed with water
  2. customdried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f01ef939869748058f52799a79c00349
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278328B2

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