HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester → 3-[5-(4-Chloro-phenyl)-pyrazin-2-yloxymethyl]-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322211 | — |
| Edukt | HCID 178516753 | HCID 178516753 | — |
| Produkt | 3-[5-(4-Chloro-phenyl)-pyrazin-2-yloxymethyl]-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322205 | — |
Reaktionsschritte
The title compound was prepared according to the method described for Preparation 29 using 5-(4-chloro-phenyl)-pyrazin-2-ol (Preparation 25) and 1-(4-fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 12) to afford the racemate as a white solid (73 mg, 20%)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08278343B2 |
| Quelldatensatz | uspto-grants-2012_10 |
| ORD ID | ord-28ac9c2c13ea4694bdcb1cdd3521a0a9 |
| Quellennotiz | uspto-grants-2012_10 |