Methyl iodide → HCID 178503939, Verbindung

HRID 2061161Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2061161
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=2)[CH:5]=[C:4]([C:13]2[CH:14]=[C:15]([NH:20][C:21]([NH:23][C:24](=[O:31])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[S:22])[CH:16]=[CH:17][C:18]=2[CH3:19])[C:3]1=[O:32].[OH-].[Na+].[CH3:35]I>C(Cl)Cl>[C:24](/[N:23]=[C:21](\[S:22][CH3:35])/[NH:20][C:15]1[CH:16]=[CH:17][C:18]([CH3:19])=[C:13]([C:4]2[C:3](=[O:32])[N:2]([CH3:1])[C:11]3[C:6]([CH:5]=2)=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=3)[CH:14]=1)(=[O:31])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 59212331HCID 59212331, Verbindung

Produkt 1

HCID 178503939HCID 178503939, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenylcarbamothioyl)benzamide 20 (22 mg, 0.05 mmol) in DCM (0.5 mL) was added solid powder of NaOH (20 mg, 0.5 mmol) and MeI (7 mg, 0.05 mmol). The mixture was stirred at rt for 1 h to yield (Z)-methyl N′-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamimidothioate 21 after removal of DCM. The crude 21 was used without further purification. MS m/z 457.2 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-db42613024ce49dea5a0727bc206f829
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278452B2

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