Thiourea → HCID 68428752, Verbindung
Reaktionsgleichung
[Br:1][CH2:2][C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6].[NH2:13][C:14]([NH2:16])=[S:15]>CO>[BrH:1].[NH2:16][C:14](=[NH:13])[S:15][CH2:2][C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[C:5]([O:7][CH3:8])=[O:6]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of the crude bromide from Step 1 (7.2 g, 0.031 mmol) and thiourea (2.6 g, 35 mmol) in MeOH (40 mL) was heated to reflux for 4 h, cooled to room temperature, and concentrated to afford methyl 2-({[amino(imino)methyl]thio}methyl)benzoate hydrobromide (10 g, ca. 100%), which was used without purification.
Aufarbeitung
- temperaturewas heated
- temperatureto reflux for 4 h
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-c0caefec248e4428b21865a23c155e62
- Quelldatensatz
- uspto-grants-2012_10
- Patentnummer
- US08283373B2
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